Doctor Octopus is planning the crowning caper of his criminal career... TO RULE THE WORLD! He has reunited the Sinister Six: Electro, Sandman, Mysterio, The Vulture and Hobgoblin. Nothing stands in the way of these reunited Super Villains... except your friendly neighborhood Spider-Man!
Can Spidey save the world? Are his super-powers enough to defeat the Sinister Six or is this more than even Spider-Man can handle? Only you hold the answer because YOU are Spider-Man, swinging into the hottest Game Gear adventure yet!